REFERENCE TABLE
Compound Half-Life & Pharmacokinetics Reference
Elimination half-life, time to peak (tMax), steady-state timing, and typical dosing for 25+ peptides, GLP-1 medications, testosterone esters, HRT compounds, and ancillaries. Your go-to PK reference table.
Half-life values are sourced from published pharmacokinetic (PK) studies and FDA prescribing information. Individual drug clearance varies based on injection site, metabolism, body composition, and carrier oil. These are reference estimates, not clinical recommendations.
GLP-1
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| SemaglutideOzempic, Wegovy | ~7 days (168 hrs) | 1-3 days | 0.25-2.4 mg | Weekly | 4-5 weeks | Subcutaneous |
| TirzepatideMounjaro, Zepbound | ~5 days (120 hrs) | 8-72 hrs | 2.5-15 mg | Weekly | 4 weeks | Subcutaneous |
| Retatrutide | ~6 days (144 hrs) | 24-36 hrs | 1-12 mg | Weekly | 4-5 weeks | Subcutaneous |
| LiraglutideSaxenda, Victoza | ~13 hrs | 8-12 hrs | 0.6-3.0 mg | Daily | 3-5 days | Subcutaneous |
Testosterone / TRT
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| Testosterone CypionateDepo-Testosterone | ~8 days (192 hrs) | 24-48 hrs (IM) | 100-200 mg/wk | 1-7x weekly | 4-6 weeks | IM or SubQ |
| Testosterone EnanthateDelatestryl | ~4.5 days (108 hrs) | 24-48 hrs (IM) | 100-200 mg/wk | 1-7x weekly | 3-4 weeks | IM or SubQ |
| Testosterone Propionate | ~20 hrs | 2-4 hrs (IM) | 25-50 mg | EOD or daily | 4-5 days | IM or SubQ |
| Testosterone UndecanoateNebido, Aveed | ~21 days | 7-14 days | 750-1000 mg | Every 10-14 weeks | ~6 months | IM |
Peptide
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| BPC-157 | ~4-6 hrs | ~30 min | 250-500 mcg | 1-2x daily | 1-2 days | Subcutaneous |
| TB-500Thymosin Beta-4 | ~2 hrs | ~15 min | 2-5 mg | 2x weekly | 1-2 weeks | Subcutaneous |
| CJC-1295 (with DAC) | ~6-8 days | 1-4 hrs | 1-2 mg | Weekly | 4-5 weeks | Subcutaneous |
| CJC-1295 (no DAC) / Mod GRF | ~30 min | ~5-15 min | 100-300 mcg | 1-3x daily | Same day | Subcutaneous |
| Ipamorelin | ~2 hrs | ~15-30 min | 100-300 mcg | 1-3x daily | Same day | Subcutaneous |
| Sermorelin | ~10-20 min | ~5-10 min | 200-500 mcg | Daily (before bed) | Same day | Subcutaneous |
| GHK-Cu | ~30-60 min | ~15 min | 1-3 mg | Daily | Same day | Subcutaneous / Topical |
| PT-141Bremelanotide (Vyleesi) | ~2.7 hrs | ~1 hr | 1-2 mg | As needed | N/A | Subcutaneous |
| MOTS-c | ~4-6 hrs (est.) | ~1-2 hrs | 5-10 mg | 3-5x weekly | 1-2 weeks | Subcutaneous |
| MK-677 (Ibutamoren) | ~5 hrs | ~2 hrs | 10-25 mg | Daily (oral) | 1-2 days | Oral |
Growth Hormone
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| HGH (Somatropin)Genotropin, Norditropin | ~3-5 hrs | 1-3 hrs | 1-4 IU | Daily | 1-2 days | Subcutaneous |
HRT
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| Estradiol CypionateDepo-Estradiol | ~8-10 days | 3-6 days | 1-5 mg | Every 1-2 weeks | 5-6 weeks | IM |
| Estradiol ValerateDelestrogen | ~3-5 days | 1-2 days | 2-20 mg | Every 1-2 weeks | 3-4 weeks | IM |
| Progesterone (Oral)Prometrium | ~5-10 hrs | 1-4 hrs | 100-200 mg | Daily | 2-3 days | Oral |
PCT / Ancillary
| Compound | Half-Life | Time to Peak | Typical Dose | Frequency | Steady State | Route |
|---|---|---|---|---|---|---|
| HCGPregnyl, Novarel | ~29-36 hrs | 6-12 hrs | 250-1000 IU | 2-3x weekly | 1-2 weeks | Subcutaneous / IM |
| AnastrozoleArimidex | ~46 hrs | ~2 hrs | 0.25-1 mg | 2-3x weekly | 7-10 days | Oral |
| Enclomiphene | ~10 hrs | ~2-6 hrs | 12.5-25 mg | Daily | 2-3 days | Oral |
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Understanding Half-Life Data
Disclaimer: This pharmacokinetic data is for informational and educational purposes only. It is not medical advice. Always consult your physician or prescribing provider before starting, stopping, or changing any medication. Regimen is a tracking tool, not a substitute for professional medical guidance.